The Anti-hemorrhagic Vitamin
1937; Elsevier BV; Volume: 16; Issue: 3 Linguagem: Inglês
10.3382/ps.0160166
ISSN1525-3171
Autores Tópico(s)Vitamin K Research Studies
ResumoA. PRELIMINARY INDICATIONS OF EXISTENCE INDICATIONS of the existence of a dietary disease in which chickens suffer from hemorrhagic tendencies and delayed blood clotting may be seen in a number of papers describing results obtained in experiments dealing with various phases of poultry nutrition. During work on the sterol metabolism of chicks, Dam (1929, 1930) observed that the animals often exhibited internal, subcutaneous, and intra-muscular hemorrhages. These symptoms were accompanied by ulcerative changes in the horny stratum of the gizzard. In a subsequent paper (1934), he showed that the disease was not caused by lack of vitamins A, D, B1, B2, C and of “fat” or cholesterol. The suggestion was made that, since a diet containing certain common feedstuffs did not produce the disease, a new dietary factor must be involved. McFarlane, Graham, and Richardson (1931) in work on the fat-soluble vitamin requirements of the chick observed hemorrhages and loss . . .
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