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The Effect of An Anticomplementary Factor on Normal Human Tears

1981; Elsevier BV; Volume: 92; Issue: 1 Linguagem: Inglês

10.1016/s0002-9394(14)75903-3

1879-1891

Aize Kijlstra, Robert Veerhuis,

Pediatric health and respiratory diseases

We used a sensitive microtechnique to assay the classic complement pathway in stimulated normal human tears. No activity was detected. However, tears of all 11 normal individuals tested contained substances that strongly interfered with the complement-mediated lysis of antibody-coated red blood cells. Preliminary characterization of the anticomplementary activity showed that it is heat-stable and has a molecular weight of approximately 150,000. We used a sensitive microtechnique to assay the classic complement pathway in stimulated normal human tears. No activity was detected. However, tears of all 11 normal individuals tested contained substances that strongly interfered with the complement-mediated lysis of antibody-coated red blood cells. Preliminary characterization of the anticomplementary activity showed that it is heat-stable and has a molecular weight of approximately 150,000.