Bestatin inhibits covalent coupling of [ 3 H]LTA 4 to human leukocyte LTA 4 hydrolase
1992; Wiley; Volume: 297; Issue: 1-2 Linguagem: Inglês
10.1016/0014-5793(92)80345-h
ISSN1873-3468
AutoresJilly F. Evans, Stacia Kargman,
Tópico(s)Antifungal resistance and susceptibility
ResumoThe covalent coupling of [3H]LTA4 to human leukocyte LTA4 hydrolase is inhibited in a concentration-dependent fashion by pre-incubation with bestatin. This inhibition correlated with the concentration-dependent inhibition by bestatin of LTB4 and LTB5 synthesis by LTA4 hydrolase. Epibestatin, a diastereomer of bestatin, neither inhibited LTB4 or LTB5 production by LTA4 hydrolase nor prevented the covalent coupling of [3H]LTA4 to the enzyme. In contrast, captopril inhibited both LTB4 synthesis by LTA4 hydrolase and covalent coupling of [3H]LTA4 to the enzyme.
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