Portal de Periódicos da CAPES

Relationship between tissue Doppler-derived RV systolic function and invasive hemodynamic measurements

2007; American Physical Society; Volume: 293; Issue: 1 Linguagem: Inglês

10.1152/ajpheart.00097.2007

1522-1539

Yasutomo Hori, Takuto Kano, Fumio Hoshi, Seiichi Higuchi,

Cardiac Imaging and Diagnostics

Tissue Doppler imaging (TDI) is effective in assessing right ventricular (RV) function, but the relationship between invasive measurements and RV-TDI remains unclear. We investigated the RV systolic function by using the TDI-derived systolic myocardial (Sa) velocity and myocardial performance index (MPI). Beagles ( n = 7) were anesthetized in the right lateral recumbent position. A 3.5-Fr micromanometer-tipped catheter was placed in the RV to determine the hemodynamic changes. Dobutamine (5.0 and 10 μg·kg −1 ·min −1 ) and esmolol (50 and 100 μg·kg −1 ·min −1 ) were infused intravenously. Pulsed Doppler (PD) and TDI measurements were performed in the apical four-chamber view. Compared with baseline, the PD-MPI decreased significantly with the dobutamine infusion at 5 μg·kg −1 ·min −1 ( P < 0.05). Both dobutamine infusions significantly decreased the TDI-MPI ( P < 0.01, P < 0.05). Esmolol increased the PD- and TDI-MPI but not significantly. Dobutamine significantly increased the Sa velocity (both P < 0.001), whereas esmolol had no effect. The Sa velocity was strongly correlated with the peak positive derivative of the RV pressure (+dP/dt; r = 0.93). The negative correlation between the +dP/dt and TDI-MPI ( r = −086) was greater that with the PD-MPI ( r = −0.54). Stepwise regression analysis showed that the Sa velocity and PD-derived isovolumic contraction time were identified to predict the +dP/dt ( r = 0.94, r 2 = 0.89; P < 0.001). We determined that the systolic myocardial velocity and TDI-MPI were strongly correlated with the RV contractility. These results suggest that the TDI-derived systolic myocardial velocity and MPI predict RV systolic function.