The anti-curare action of sodium fluoride at the neuromuscular junction of cat tenuissimus muscle
1971; Elsevier BV; Volume: 10; Issue: 5 Linguagem: Inglês
10.1016/0028-3908(71)90026-8
ISSN1873-7064
AutoresRobert S. Jacobs, L.C. Blaber,
Tópico(s)Advanced Sensor and Energy Harvesting Materials
ResumoAbstract The anti-curare action of sodium fluoride was investigated in cat tenuissimus muscle by means of intracellular micro-electrode techniques. Eight millimoles of sodium fluoride augmented the amplitude of end-plate potentials in the presence of d -tubocurarine by elevating quantal content. This presynaptic effect was consistent with a concomitant rise in readily releasable stores of transmitter. In the absence of d -tubocurarine, eight millimoles of sodium fluoride depressed end-plate potential amplitude and prolonged half-decay. These latter responses appear to be in part the result of a depressant action of sodium fluoride on transmitter mobilization rate.
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