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Urinary Collecting System Invasion is an Independent Prognostic Factor of Organ Confined Renal Cell Carcinoma

2009; Lippincott Williams & Wilkins; Volume: 182; Issue: 3 Linguagem: Inglês

10.1016/j.juro.2009.05.017

1527-3792

G. Verhoest, Р. Авакян, Karim Bensalah, Rodolphe Thuret, Vincenzo Ficarra, Walter Artibani, Jacques Tostain, F. Guillé, L. Cindolo, Alexandre de la Taille, Claude-Clément Abbou, Laurent Salomon, Nathalie Rioux‐Leclercq, Jean‐Jacques Patard,

Renal and related cancers

No AccessJournal of UrologyAdult Urology1 Sep 2009Urinary Collecting System Invasion is an Independent Prognostic Factor of Organ Confined Renal Cell Carcinoma Grégory Verhoest, Raffi Avakian, Karim Bensalah, Rodolphe Thuret, Vincenzo Ficarra, Walter Artibani, Jacques Tostain, François Guille, Lucas Cindolo, Alexandre De La Taille, Claude-Clément Abbou, Laurent Salomon, Nathalie Rioux-Leclercq, and Jean-Jacques Patard Grégory VerhoestGrégory Verhoest Rennes University Hospital, Rennes, France , Raffi AvakianRaffi Avakian Rennes University Hospital, Rennes, France , Karim BensalahKarim Bensalah Rennes University Hospital, Rennes, France , Rodolphe ThuretRodolphe Thuret Montpellier University Hospital, France , Vincenzo FicarraVincenzo Ficarra Padova University Hospital, Padua, Italy , Walter ArtibaniWalter Artibani Padova University Hospital, Padua, Italy , Jacques TostainJacques Tostain Saint-Etienne University, Saint-Etienne, France , François GuilleFrançois Guille Rennes University Hospital, Rennes, France , Lucas CindoloLucas Cindolo G. Rummo Hospital, Benevento, Italy , Alexandre De La TailleAlexandre De La Taille Henri Mondor University Hospital, Créteil, France , Claude-Clément AbbouClaude-Clément Abbou Henri Mondor University Hospital, Créteil, France , Laurent SalomonLaurent Salomon Henri Mondor University Hospital, Créteil, France , Nathalie Rioux-LeclercqNathalie Rioux-Leclercq Rennes University Hospital, Rennes, France , and Jean-Jacques PatardJean-Jacques Patard Rennes University Hospital, Rennes, France View All Author Informationhttps://doi.org/10.1016/j.juro.2009.05.017AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated urinary collecting system invasion as a prognostic parameter of renal cell carcinoma. Materials and Methods: A total of 1,124 patients who underwent nephrectomy for a renal tumor at 5 European centers were included in this retrospective study. Several variables were analyzed including urinary collecting system invasion, age, sex, TNM stage, Fuhrman grade, histological subtype, Eastern Cooperative Oncology Group performance status and cancer specific survival. Results: There were 771 males (68.6%) and 353 females (31.4%) in this study, and median age was 61 years (range 14 to 88). Median tumor size was 6 cm (range 1 to 24). Tumors were organ confined and Fuhrman grade was recorded as 1 or 2 in 67.1% and 62.3% of cases, respectively. Symptoms were present at diagnosis, and Eastern Cooperative Oncology Group performance status was 1 or more in 50.3% and 16.1% of the cases, respectively. Median followup was 43 months (range 1 to 299). At the end of followup 246 patients (21.9%) died of cancer. In 132 cases (11.7%) urinary collecting system invasion was noted. Urinary collecting system invasion was associated with symptoms, TNM stage, Fuhrman grade, tumor size (p <0.001) and Eastern Cooperative Oncology Group performance status (p = 0.003), but not with histological subtype (p = 0.7). On univariate analysis TNM stage, Fuhrman grade, symptoms, Eastern Cooperative Oncology Group performance status, tumor size and urinary collecting system invasion (p = 0.0001) were significant predictors of cancer specific survival. Urinary collecting system invasion was an independent prognostic parameter only in the setting of pT1–T2 tumors. When the urinary collecting system was invaded the 5 and 10-year probabilities of survival were 43% and 41%, respectively. Conclusions: Urinary collecting system invasion appears to be an independent prognostic parameter of organ confined renal cell carcinoma. Our data support the need to integrate this parameter in further TNM revisions. References 1 : The changing natural history of renal cell carcinoma. 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Link, Google Scholar © 2009 by American Urological AssociationFiguresReferencesRelatedDetailsCited bySaroha S, Uzzo R, Plimack E, Ruth K and Al-Saleem T (2018) Lymphopenia is an Independent Predictor of Inferior Outcome in Clear Cell Renal CarcinomaJournal of Urology, VOL. 189, NO. 2, (454-461), Online publication date: 1-Feb-2013.Brookman-May S, May M, Zigeuner R, Shariat S, Scherr D, Chromecki T, Moch H, Wild P, Mohamad-Al-Ali B, Cindolo L, Wieland W, Schips L, De Cobelli O, Rocco B, Santoro L, De Nunzio C, Tubaro A, Coman I, Feciche B, Truss M, Dalpiaz O, Hohenfellner M, Gilfrich C, Wirth M, Burger M and Pahernik S (2018) Collecting System Invasion and Fuhrman Grade But Not Tumor Size Facilitate Prognostic Stratification of Patients With pT2 Renal Cell CarcinomaJournal of Urology, VOL. 186, NO. 6, (2175-2181), Online publication date: 1-Dec-2011. Volume 182Issue 3September 2009Page: 854-859 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordskidney neoplasmspathologynephrectomyMetricsAuthor Information Grégory Verhoest Rennes University Hospital, Rennes, France More articles by this author Raffi Avakian Rennes University Hospital, Rennes, France More articles by this author Karim Bensalah Rennes University Hospital, Rennes, France More articles by this author Rodolphe Thuret Montpellier University Hospital, France More articles by this author Vincenzo Ficarra Padova University Hospital, Padua, Italy More articles by this author Walter Artibani Padova University Hospital, Padua, Italy More articles by this author Jacques Tostain Saint-Etienne University, Saint-Etienne, France More articles by this author François Guille Rennes University Hospital, Rennes, France More articles by this author Lucas Cindolo G. Rummo Hospital, Benevento, Italy More articles by this author Alexandre De La Taille Henri Mondor University Hospital, Créteil, France More articles by this author Claude-Clément Abbou Henri Mondor University Hospital, Créteil, France More articles by this author Laurent Salomon Henri Mondor University Hospital, Créteil, France More articles by this author Nathalie Rioux-Leclercq Rennes University Hospital, Rennes, France More articles by this author Jean-Jacques Patard Rennes University Hospital, Rennes, France More articles by this author Expand All Advertisement PDF downloadLoading ...