Cloning and Characterization of the Genomic RNA Sequence of the Mumps Virus Strain Associated with a High Incidence of Aseptic Meningitis
1998; Wiley; Volume: 42; Issue: 2 Linguagem: Inglês
10.1111/j.1348-0421.1998.tb02262.x
ISSN1348-0421
AutoresHiroyuki Saito, Yoshihiro Takahashi, Seizaburo Harata, Keiko Tanaka, Hiroyasu Sato, Tsunehisa Suto, Akio Yamada, Shudo Yamazaki, M Morita,
Tópico(s)Bacteriophages and microbial interactions
ResumocDNA clones of the mumps virus wild-type strain, associated with a high incidence of aseptic meningitis (ODATE-1 strain), were isolated and analyzed from genomic nucleotide position 22 to 8520 containing the NP, P, M, F, SH and HN protein coding region. The ODATE-1 strain exhibited a RFLP profile identical to that of the Urabe vaccine strain in spite of the fact that the virus was isolated from non-vaccinated cases. However, a comparison of nucleotide and amino acid sequences among the ODATE-1 strain, Urabe strain and Miyahara strain revealed that the ODATE-1 strain was not related to the Urabe strain.
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