Produção Nacional
Revisado por pares
The Use of Endophytes to Obtain Bioactive Compounds and Their Application in Biotransformation Process
2010; Hindawi Publishing Corporation; Volume: 2011; Linguagem: Inglês
10.4061/2011/576286
ISSN2090-3138
AutoresMariana R. Pimentel, Gustavo Molina, Ana Paula Dionísio, Mário Roberto Maróstica, Gláucia María Pastore,
Tópico(s)Chromatography in Natural Products
ResumoEndophytes are microorganisms that reside asymptomatically in the tissues of higher plants and are a promising source of novel organic natural metabolites exhibiting a variety of biological activities. The laboratory of Bioaromas (Unicamp, Brazil) develops research in biotransformation processes and functional evaluation of natural products. With the intent to provide subsidies for studies on endophytic microbes related to areas cited before, this paper focuses particularly on the role of endophytes on the production of anticancer, antimicrobial, and antioxidant compounds and includes examples that illustrate their potential for human use. It also describes biotransformation as an auspicious method to obtain novel bioactive compounds from microbes. Biotransformation allows the production of regio- and stereoselective compounds under mild conditions that can be labeled as "natural," as discussed in this paper.
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