Application of laser-accelerated protons to the demonstration of DNA double-strand breaks in human cancer cells
2009; American Institute of Physics; Volume: 94; Issue: 18 Linguagem: Inglês
10.1063/1.3126452
ISSN1520-8842
AutoresA. Yogo, Katsutoshi Sato, Masaharu Nishikino, M. Mori, T. Teshima, Hodaka Numasaki, M. Murakami, Yusuke Demizu, Shinsuke Akagi, Shin Nagayama, Koichi Ogura, A. Sagisaka, Satoshi Orimo, Mamiko Nishiuchi, A. S. Pirozhkov, M. Ikegami, M. Tampo, H. Sakaki, Kenji Suzuki, I. Daito, Y. Oishi, Hironori Sugiyama, Hiromitsu Kiriyama, Hajime Okada, Shuhei Kanazawa, S. Kondo, Takuya Shimomura, Yoshiki Nakai, Manabu Tanoue, H. Sasao, Daisuke Wakai, Paul R. Bolton, Hiroyuki Daido,
Tópico(s)Nuclear Physics and Applications
ResumoWe report the demonstrated irradiation effect of laser-accelerated protons on human cancer cells. In vitro (living) A549 cells are irradiated with quasimonoenergetic proton bunches of 0.8–2.4 MeV with a single bunch duration of 15 ns. Irradiation with the proton dose of 20 Gy results in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks generated in the cancer cells. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. Unique high-current and short-bunch features make laser-driven proton bunches an excitation source for time-resolved determination of radical yields.
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