Portal de Periódicos da CAPES

Effects of superoxide dismutase and catalase on central nervous system toxicity of hyperbaric oxygen

1980; Elsevier BV; Volume: 53; Issue: 1 Linguagem: Inglês

10.1016/0041-008x(80)90380-4

1096-0333

James G. Hilton, Gill Brown, Peter Proctor,

Hemoglobin structure and function

The effects of exogenous superoxide dismutase (SOD) (20 mg/kg) and catalase (3.0 mg/kg) and the combination of SOD + catalase upon the time to convulsions following 100% oxygen at 3 and 6 atm have been studied in mice. SOD alone produced no change in the time to convulsions, catalase produced a prolongation of approximately 50% of the time to convulsions observed in the untreated mice, and SOD when administered with the catalase interfered with the catalase response. Graded doses of catalase produced a graded prolongation of time to convulsions, demonstrating a dose-response relationship. These findings are compatible with previous investigations showing an increase in brain H2O2 with exposure to hyperbaric oxygen, which may infer that this substance plays a part in the CNS toxicity observed.