The pharmacokinetic basis of insulin therapy in diabetes mellitus
1989; Elsevier BV; Volume: 6; Issue: 4 Linguagem: Inglês
10.1016/0168-8227(89)90073-9
ISSN1872-8227
Autores Tópico(s)Pancreatic function and diabetes
ResumoAlthough insulin has been used in the therapy of both type 1 (IDDM) and type 2 diabetes (NIDDM) for almost 70 years, it is only during the last lo-15 years that a rational approach to insulin therapy has clearly been defined. The recent progress of our knowledge of the pharmacokinetics and pharmacodynamics of insulin have greatly contributed to the present understanding of the appropriate use of insulin, in intensive as well as non-intensive therapy regimens. In this paper, the definition of insulin pharmacokinetics and pharmacodynamics, the problems of the route of insulin delivery, and the factors which are most commonly relevant to the pharmacokinetics of subcutaneously injected (or infused) insulin will be reviewed. Finally, the models of intensive as well as non-intensive insulin therapy will be briefly discussed.
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