Tiagabine-related non-convulsive status epilepticus in partial epilepsy: three case reports and a review of the literature
2002; Elsevier BV; Volume: 11; Issue: 4 Linguagem: Inglês
10.1053/seiz.2001.0594
ISSN1532-2688
AutoresChristoph Kellinghaus, Rainer Dziewas, Peter Lüdemann,
Tópico(s)Cardiac electrophysiology and arrhythmias
ResumoThere have been several recent reports of non-convulsive status epilepticus during tiagabine therapy in patients with partial epilepsy. We report three cases where elevation of tiagabine dosage was followed by electroclinical features, or electroencephalographic features without clinical signs, of non-convulsive status epilepticus. Administration of clonazepam and/or discontinuation to tiagabine lead to complete remission. In one case after re-exhibition of tiagabine the EEG again showed rhythmic delta waves. We review the other cases reported so far and discuss the different pathophysiological hypotheses about the association in the light of new experimental data.
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