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The intracellular localization of Δ9-tetrahydrocannabinol in liver and its effects on drug metabolism in vitro

1973; Elsevier BV; Volume: 22; Issue: 8 Linguagem: Inglês

10.1016/0006-2952(73)90219-0

1873-2968

James V. Dingell, Kenneth W. Miller, Eugene C. Heath, Howard Klausner,

Drug Transport and Resistance Mechanisms

In the hepatic cell Δ9-tetrahydrocannabinol (THC) is localized in nuclei and microsomes. The intracellular binding of THC affects hepatic drug metabolism: nuclei markedly reduce the metabolism of THC by hepatic microsomes; THC inhibits the microsomal oxidation of aminopyrine and hexobarbital, the conjugation of estradiol and p-nitrophenol and enhances the reduction of p-nitrobenzoic acid. The metabolism of THC, in vitro, is strikingly inhibited by SKF-525A but not by desipramine, nortriptyline and iprindole which are potent inhibitors of the oxidation of other drugs.