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Antibacterial and Anticoagulant Activities of Coumarins Isolated from the Flowers of Magydaris tomentosa

2007; Thieme Medical Publishers (Germany); Volume: 73; Issue: 2 Linguagem: Inglês

10.1055/s-2006-951772

1439-0221

Sergio Rosselli, Antonella Maggio, Gabriella Bellone, Carmen Formisano, Adriana Basile, Carla Cicala, Alessio Alfieri, Nicola Mascolo, Maurizio Bruno,

Synthesis and Biological Activity

The phytochemical investigation of the acetone and methanol extracts of the flowers of Magydaris tomentosa (Desf.) DC afforded six known coumarins as well as (+)-meranzin hydrate (7), not previously reported as a natural product. The antibacterial activity of umbelliprenin (1), osthol (2), imperatorin (3), citropten (4) and (+)-meranzin hydrate (7) was tested against Gram-positive and Gram-negative bacteria. All coumarins (1-7) isolated in this study inhibited growth of all bacterial strains tested (MIC between 16 and 256 microg/mL), the most active being imperatorin (3) (MICs between 32 and 128 microg/mL) and citropten (4) (MICs between 16 and 256 microg/mL). The anticoagulant activity of compounds 1-4 and 7 was also evaluated.