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Helical Chiral 2,2′-Bipyridine N- Monoxides as Catalysts in the Enantioselective Propargylation of Aldehydes with Allenyltrichlorosilane

2011; American Chemical Society; Volume: 13; Issue: 7 Linguagem: Inglês

10.1021/ol200102c

1523-7060

Jinshui Chen, Burjor Captain, Norito Takenaka,

Oxidative Organic Chemistry Reactions

A highly enantioselective synthesis of homopropargylic alcohols is achieved by using the new helical chiral 2,2′-bipyridine N-monoxide catalyst and allenyltrichlorosilane. This method can be further extended to the enantio- and regioselective propargylation of N-acylhydrazones.