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Management of Monoamine Oxidase Inhibitor-Associated Insomnia with Trazodone

1989; Lippincott Williams & Wilkins; Volume: 9; Issue: 1 Linguagem: Inglês

10.1097/00004714-198902000-00009

1533-712X

Andrew A. Nierenberg, Paul E. Keck,

Treatment of Major Depression

Monoamine oxidase inhibitors (MAOIs) have been reported to cause or exacerbate insomnia, sometimes requiring discontinuation despite adequate therapeutic response. The authors present a series of 13 cases of MAOI-associated insomnia managed with addition of trazodone. Twelve patients (92%) had an initial positive response, with nine (69%) able to continue on the combination of MAOI and trazodone without intolerable side effects.