Portal de Periódicos da CAPES

Mycobacterium tuberculosis ‐activated dendritic cells induce protective immunityin mice

2000; Wiley; Volume: 99; Issue: 3 Linguagem: Inglês

10.1046/j.1365-2567.2000.00963.x

1365-2567

Ricardo E. Tascon, Sandra Clara Soares, Silvia Ragno, Evangelos Stavropoulos, Elizabeth Hirst, M. Joseph Colston,

T-cell and B-cell Immunology

Activated dendritic cells are critically important in the priming of T-cell responses. In this report we show that the infection of a conditionally immortalized dendritic cell line (tsDC) with Mycobacterium tuberculosis resulted in the up-regulation of B7-1 and B7-2 co-stimulatory molecules and the induction of several inflammatory cytokines, including tumour necrosis factor-alpha and interleukin-6, -1beta and -12. In addition, we show that these activated dendritic cells were capable of eliciting antigen-specific T-cell responses and potent anti-mycobacterial protective immunity in a murine model of experimental tuberculosis infection.