Design and characterization of electrochromic membrane probes
1982; Elsevier BV; Volume: 6; Issue: 3 Linguagem: Inglês
10.1016/0165-022x(82)90047-1
ISSN1872-857X
Autores Tópico(s)Molecular Sensors and Ion Detection
ResumoElectrochromic membrane probes display a spectroscopic response to membrane poteintial by a direct electronic mechanism. This allows such probes to be designed a priori via quantum-chemical techniques. The detailed behavior of potentiometric optical probes can be elucidated with an apparatus based on phase-sensitive detection from a hemispherical lipid bilayer; several different types of response spectra can be obtained with this apparatus allowing distinction between the electrochromic mechanism and the more common molecular-motion based mechanisms. The development of 'fast' potentiometri dyes has now reached a stage where practical and exciting applications are rapidly appearing. It is anticipated that the emergence of a complementary set of electrochromic probes will lead to new applications; in particular, it may be possible to elucidate the molecular events which underlie biological or physiological phenomena.
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