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Expedient Synthesis of Potent Cannabinoid Receptor Agonist (−)-CP55,940

2005; American Chemical Society; Volume: 7; Issue: 19 Linguagem: Inglês

10.1021/ol051570c

1523-7060

Noriaki Itagaki, Tsutomu Sugahara, Yoshiharu Iwabuchi,

Neurotransmitter Receptor Influence on Behavior

[reaction: see text] A stereocontrolled synthesis of (-)-CP55,940, a potent cannabinoid receptor agonist, has been attained using a novel aldolization/retro-aldolization interconversion strategy, in which a temporarily generated chiral aldol motif plays essential roles.