A short enantioselective synthesis of 1-deoxy-l-xylulose by antibody catalysis
1999; Elsevier BV; Volume: 40; Issue: 8 Linguagem: Inglês
10.1016/s0040-4039(98)02699-9
ISSN1873-3581
AutoresDoron Shabat, Benjamin List, Richard A. Lerner, Carlos F. Barbas,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoA new efficient synthesis of 1-deoxy-l-xylulose (1) is presented. The key step is achieved by a highly enantioselective aldol addition of hydroxyacetone to benzyloxyacetaldehyde via antibody catalysis. The synthesis described here should provide a convenient route to isotopically labeled derivatives.
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