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Mitotic chromosome structure and condensation

2006; Elsevier BV; Volume: 18; Issue: 6 Linguagem: Inglês

10.1016/j.ceb.2006.09.007

1879-0410

Andrew S. Belmont,

Chromosomal and Genetic Variations

Mitotic chromosome structure has been the cell biology equivalent of a 'riddle, wrapped in a mystery, inside an enigma'. Observations that genetic knockout or knockdown of condensin subunits or topoisomerase II cause only minimal perturbation in overall chromosome condensation, together with analysis of early stages of chromosome condensation and effects produced by histone H1 depletion, suggest a need to reconsider textbook models of mitotic chromosome condensation and organization.