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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

NSAIDs revisited: Putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARγ)

2008; Elsevier BV; Volume: 43; Issue: 9 Linguagem: Inglês

10.1016/j.ejmech.2007.11.031

ISSN

1768-3254

Autores

Nelilma Correia Romeiro, Carlos Maurício R. Sant’Anna, Lı́dia Moreira Lima, Carlos Alberto Manssour Fraga, Eliezer J. Barreiro,

Tópico(s)

Eicosanoids and Hypertension Pharmacology

Resumo

This paper describes molecular docking studies of a series of classical NSAIDs with PPARgamma receptor, which has been pointed as a new target for the design of anti-cancer and anti-inflammatory drugs, and has been found to be responsible for some of the already established pharmacological effects observed for marketed drugs. The results show the molecular basis of PPARgamma activation by non-selective COX inhibitors.

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