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Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus.

1975; American Society for Clinical Investigation; Volume: 55; Issue: 6 Linguagem: Inglês

10.1172/jci108044

1558-8238

Raphael J. DeHoratius, Ronald P. Messner,

Psoriasis: Treatment and Pathogenesis

57% of sera from 124 relatives of 28 patients with systemic lupus erythematosus (SLE) were found to have antibody directed against lymphocytes. The incidence in 60 members of 16 control families was 3%. Both consanguineous and nonconsanguineous relatives had the antibody in their sera. 68% of close household contacts of the SLE patients showed lymphocytotoxic antibody whereas only 23% of consanguineous relatives who had no household contact with the probands had this antibody. These data suggest that environmental factors may be important in the pathogenesis of SLE.