Portal de Periódicos da CAPES

Boosting of Secretory IgA Antibody Responses in Man by Parenteral Cholera Vaccination

1977; Wiley; Volume: 6; Issue: 12 Linguagem: Inglês

10.1111/j.1365-3083.1977.tb00376.x

1365-3083

Ann‐Mari Svennerholm, Jan Holmgren, L. Å. Hanson, B. S. Lindblad, F. QUERESHI, Razia J. Rahimtoola,

Escherichia coli research studies

The occurrence of specific antibodies to Vibrio cholerae lipopolysaccharide in serum, milk, and saliva of Pakistani women from a very low socioeconomic group was studied before and after a single subcutaneous cholera vaccination. Before immunization all women had low levels of specific antibodies in serum, primarily of IgM class, and in many cases cholera IgA antibodies were found in milk and saliva as well, indicating earlier natural exposure. The vaccination consistently induced a marked rise in serum antibody titer, and notably also produced significant titer increases in 70% of the milk and in 45% of the saliva samples. Whereas the serum antibodies induced were predominantly of the IgG class, secretory IgA was responsible for most of the titer increase in the secretions. The results indicate that parenteral cholera vaccination can boost local secretory IgA antibody responses in intestinally primed individuals.