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Is right-sided colon cancer different to left-sided colorectal cancer? – A systematic review

2014; Elsevier BV; Volume: 41; Issue: 3 Linguagem: Inglês

10.1016/j.ejso.2014.11.001

1532-2157

Gui Han Lee, George Malietzis, Alan Askari, David Bernardo, Hafid O. Al‐Hassi, Susan K. Clark,

Colorectal Cancer Screening and Detection

Abstract Colorectal cancer (CRC) exhibits differences in incidence, pathogenesis, molecular pathways and outcome depending on the location of the tumor. This review focuses on the latest developments in epidemiological and scientific studies, which have enhanced our understanding on the underlying genetic and immunological differences between the proximal (right-sided) colon and the distal (left-sided) colorectum. The different ways in which environmental risk factors influence the pathogenesis of CRC depending on its location and the variations in surgical and oncological outcomes are also discussed in this review. In the current era of personalized medicine, we aim to reiterate the importance of tumor location in management of CRC and the implication on future clinical and scientific research.