From Genotype to Phenotype: Systems Biology Meets Natural Variation
2008; American Association for the Advancement of Science; Volume: 320; Issue: 5875 Linguagem: Inglês
10.1126/science.1153716
ISSN1095-9203
AutoresPhilip N. Benfey, Thomas Mitchell‐Olds,
Tópico(s)Biomedical Text Mining and Ontologies
ResumoThe promise that came with genome sequencing was that we would soon know what genes do, particularly genes involved in human diseases and those of importance to agriculture. We now have the full genomic sequence of human, chimpanzee, mouse, chicken, dog, worm, fly, rice, and cress, as well as those for a wide variety of other species, and yet we still have a lot of trouble figuring out what genes do. Mapping genes to their function is called the "genotype-to-phenotype problem," where phenotype is whatever is changed in the organism when a gene's function is altered.
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