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Increased T‐Cell Activation in Decidua Parietalis Compared to Decidua Basalis in Uncomplicated Human Term Pregnancy

2003; Wiley; Volume: 49; Issue: 5 Linguagem: Inglês

10.1034/j.1600-0897.2003.00041.x

1600-0897

Aliana P Sindram-Trujillo, Sicco A. Scherjon, Humphrey H.H. Kanhai, Dave L. Roelen, Frans H.J. Claas,

Reproductive Physiology in Livestock

PROBLEM: The aim of this study was to quantify and compare activated T cells in term decidua basalis and parietalis using flow cytometry. METHOD OF STUDY: Term decidua basalis and parietalis samples were obtained from 20 placentas collected after elective caesarean section. Percentages of leukocyte subclasses within the CD45 + cell fraction and activated T cells were determined by flow cytometry. RESULTS: There was no significant difference in CD45 + , CD14 + , CD19 + , and CD3 + cell percentages. However, within the CD3 + population, there were significantly more T‐cell receptor‐γδ + (TCR‐γδ + ) and CD8 + cells in decidua parietalis compared with decidua basalis. More importantly, percentages of T cells expressing CD25, human leukocyte antigen (HLA)‐DR, CD45RO, and CD69 markers were significantly increased in decidua parietalis. CONCLUSION: These findings suggest that there are more activated T cells in decidua parietalis than in decidua basalis. Further investigation into differences between the two decidual sites may expand our understanding of the immunology of the maternal–fetal interface.