Paraneoplastische Retinopathie unter dem klinischen Bild einer Zapfendystrophie mit Achromatopsie
1990; Thieme Medical Publishers (Germany); Volume: 197; Issue: 08 Linguagem: Inglês
10.1055/s-2008-1046260
ISSN1439-3999
AutoresDavid G. Cogan, Toichiro Kuwabara, J. Currie, Jorge C. Kattah,
Tópico(s)Drug-Induced Ocular Toxicity
ResumoA 72-year-old woman developed recurrent blindness on exposure to bright light (sunlight). Examination revealed total achromatopsia; bilateral central scotomas, predominant suppression of the cone response by electroretinography, and narrowing of the retinal arteries on ophthalmoscopy. The general examination revealed a pelvic tumor that later proved to be a pleomorphic carcinoma of presumed uterine origin. The patient died of metastatic disease 9 months after the ocular symptoms developed. Histopathologic examination of the eyes revealed loss of the photoreceptors, most extensive in the macular regions, and selective loss of the cones from the rest of the retinas. No ocular metastases of inflammation were found. The changes described are interpreted as paraneoplastic retinopathy of autoimmune origin.
Referência(s)