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Assessment of progression and prognosis in ?possible? and ?probable? Alzheimer's disease

1998; Wiley; Volume: 13; Issue: 5 Linguagem: Inglês

10.1002/(sici)1099-1166(199805)13

1099-1166

Greg Swanwick, Robert F. Coen, Davis Coakley, Brian Lawlor,

Health Systems, Economic Evaluations, Quality of Life

International Journal of Geriatric PsychiatryVolume 13, Issue 5 p. 331-335 Research Article Assessment of progression and prognosis in 'possible' and 'probable' Alzheimer's disease G. R. J. Swanwick Senior Registrar in the Psychiatry of Old Age, Corresponding Author G. R. J. Swanwick Senior Registrar in the Psychiatry of Old Age Mercer's Institute for Research on Ageing, St James's Hospital, Dublin, IrelandMercer's Institute for Research on Ageing, St James's Hospital, James's St, Dublin 8, Ireland. Tel: 353-1-453 7941, Ext. 2640. Fax: 353-1-4541796.Search for more papers by this authorR. F. Coen Research Psychologist, R. F. Coen Research Psychologist Mercer's Institute for Research on Ageing, St James's Hospital, Dublin, IrelandSearch for more papers by this authorD. Coakley Professor of Geriatric Medicine, D. Coakley Professor of Geriatric Medicine Mercer's Institute for Research on Ageing, St James's Hospital, Dublin, IrelandSearch for more papers by this authorB. A. Lawlor Consultant Psychiatrist, B. A. Lawlor Consultant Psychiatrist Mercer's Institute for Research on Ageing, St James's Hospital, Dublin, Ireland Department of Psychiatry, St James's Hospital, Dublin, IrelandSearch for more papers by this author G. R. J. Swanwick Senior Registrar in the Psychiatry of Old Age, Corresponding Author G. R. J. Swanwick Senior Registrar in the Psychiatry of Old Age Mercer's Institute for Research on Ageing, St James's Hospital, Dublin, IrelandMercer's Institute for Research on Ageing, St James's Hospital, James's St, Dublin 8, Ireland. Tel: 353-1-453 7941, Ext. 2640. Fax: 353-1-4541796.Search for more papers by this authorR. F. Coen Research Psychologist, R. F. Coen Research Psychologist Mercer's Institute for Research on Ageing, St James's Hospital, Dublin, IrelandSearch for more papers by this authorD. Coakley Professor of Geriatric Medicine, D. Coakley Professor of Geriatric Medicine Mercer's Institute for Research on Ageing, St James's Hospital, Dublin, IrelandSearch for more papers by this authorB. A. Lawlor Consultant Psychiatrist, B. A. Lawlor Consultant Psychiatrist Mercer's Institute for Research on Ageing, St James's Hospital, Dublin, Ireland Department of Psychiatry, St James's Hospital, Dublin, IrelandSearch for more papers by this author First published: 04 December 1998 https://doi.org/10.1002/(SICI)1099-1166(199805)13:5 3.0.CO;2-QCitations: 10AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Objective. The objective of this study was to assess the rate of progression and clinical predictors of decline in subjects with 'possible' and 'probable' Alzheimer's disease (AD). Design/setting. The annual rate of change (ARC) for cognitive/functional scales was calculated for 95 subjects with AD attending a memory clinic. Two consecutive ARCs were calculated for a subgroup of 39 subjects. Results. The ARCs were relatively normally distributed; however, there was a large degree of variability. Neither age nor duration of symptoms at presentations were predictive of the rate of decline. However, the data suggested an effect of gender, with males having a greater rate of decline in cognition (p=0·02). Finally, the rate of progression over the first year did not predict the subsequent ARC (p=0·25). Conclusions. 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