Ultrastructure of the acinic cell carcinoma and clear cell carcinoma of the parotid gland
1967; Wiley; Volume: 20; Issue: 4 Linguagem: Inglês
10.1002/1097-0142(1967)20
ISSN1097-0142
Autores Tópico(s)Colorectal and Anal Carcinomas
ResumoCancerVolume 20, Issue 4 p. 563-571 ArticleFree Access Ultrastructure of the acinic cell carcinoma and clear cell carcinoma of the parotid gland Rene A. Echevarria MD, Rene A. Echevarria MD Division of Surgical Pathology, Department of Pathology, Washington University School of Medicine and Barnes Hospital, St. Louis, Mo. 63110 Post Doctoral Trainee, U.S. Public Health Service Grant 5TI GM 897–05.Search for more papers by this author Rene A. Echevarria MD, Rene A. Echevarria MD Division of Surgical Pathology, Department of Pathology, Washington University School of Medicine and Barnes Hospital, St. Louis, Mo. 63110 Post Doctoral Trainee, U.S. Public Health Service Grant 5TI GM 897–05.Search for more papers by this author First published: 1967 https://doi.org/10.1002/1097-0142(1967)20:4 3.0.CO;2-WCitations: 67 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The acinic cell carcinoma and the clear cell carcinoma of the parotid are morphologically different neoplasms under electron microscopic examination. The former appears as a differentiated tumor, made of secretory serous acinar cells. The latter seems to arise from striated ducts and is composed of peculiar clear cells. These clear cells contain a large number of free ribosomes, a few mitochondria and very few other organelles. The "clear" appearance of the cytoplasm results from clumping and margination of the ribosomes after formalin fixation. These cells seem to be undifferentiated tumor cells with an RNA deficient ribosomal apparatus, which would partly explain the slow growth of these tumors. References 1 Abrams, A. M., Cornyn, J., Scofield, H. H., and Hansen, L. S.: Acinic cell adenocarcinoma of the major salivary glands—A clinicopathologic study of 77 cases. Cancer 18: 1145– 1162, 1965. 2 Armstrong, J. A.: Histochemical differentiation of nucleic acids by means of induced fluorescence. Exp. Cell Res. 11: 640– 643, 1956. 3 Azzopardi, J. G., and Smith, O. D.: Salivary gland tumors and their mucins. J. Path. Bact. 77: 131– 140, 1959. 4 Bauer, W. J., and Bauer, J. D.: Classification of glandular tumors of salivary glands—Study of 143 cases. AMA Arch. Path. 55: 328– 346, 1953. 5 Bhaskar, S. N., and Bernier, J. L.: Mucoepidermoid tumors of major and minor salivary glands—Clinical features, histology, variations, natural history and results of treatment for 144 cases. Cancer 15: 801– 817, 1962. 6 Ericsson, J. L. E., Trump, B. F., and Weibel, J.: Electron microscopic studies of the proximal tubule of the rat kidney—II. Cytosegresomes and cytosomes— Their relationship to each other and to the lisosome concept. Lab. Invest. 14: 1341– 1365, 1965. 7 Estable-Puig, J. F., Bauer, W. C., and Blumberg, J. M.: Technical Note—Paraphenylenediamine staining of osmium fixed plastic embedded tissue for light and phase microscopy. J. Neuropath. Exp. Neuro. 24: 531– 535, 1965. 8 Ferner, H., and Gansler, H.: Electronenmikros-kopische untersuchungen an der glandula submandibularis und parotid des menschen. Z. Zellforsch 55: 148– 178, 1961. 9 Foote, F. W., and Frazell, E. L.: Tumors of the major salivary glands. Cancer 6: 1065– 1133, 1953. 10 Fox, N. M., Jr., Remine, W. H., and Woolner, L. B.: Acinic cell carcinoma of the major salivary glands, Am. J. Surg. 106: 860– 867, 1963. 11 Franssen, R.: Eine parathyreoidea-ähnliche—Geschwulst der Ohrspeicheldrüsen. Centralbl. Allg. Path. Path. Anat. 56: 113– 115, 1932. 12 Godwin, J. T., Foote, F. W., and Frazell, E. L.: Acinic cell adenocarcinoma of the parotid gland— Report of 27 cases. Am. J. Path. 30: 465– 477, 1954. 13 Hückel, R.: Eine ungewöhnliche adenomform der parotis. Verhandl. Deutsch. Path. Gesellsch. 25: 342– 347, 1930. 14 Palade, G. E.: A small particulate component of the cytoplasm. In Frontiers in Cytology. New Haven, Yale University Press, 1958; pp. 283– 304. 15 Parks, H. F.: On the fine structure of the parotid gland of mouse and rat. Am. J. Anat. 108: 303– 329, 1961. 16 Parks, H. F.: Morphological study of the extrusion of secretory materials by the parotid glands of the mouse and rat. J. Ultrastruct. Res. 6: 449– 465, 1962. 17 Pease, D. C.: Infolded basal plasma membranes found in epithelia noted for their water transport. J. Biophys. Biochem. Cytol. Suppl. 2: 203– 208, 1956. 18 Rawson, A. J., Howard, J. M., Royster, H. P., and Horn, R. C.: Tumors of the salivary glands—A clinicopathologic study of 160 cases. Cancer 3: 445– 458, 1950. 19 Revel, J. P.: The electron microscopy of glycogen. J. Histochem. Cytochem. 12: 104– 114, 1964. 20 Reynolds, E. S.: The use of lead citrate at high pH as an electron opaque stain in electron microscopy. J. Cell Biol. 17: 208– 212, 1963. 21 Rivlin, R. S.: Acinic cell adenocarcinoma of the parotid gland. Am. J. Surg. 100: 639– 642, 1960. 22 Roth, S. I., Olen, E., and Hansen, L. S.: The eosinophilic cells of the parathyroid (oxyphil cells), salivary (oncocytes), and thyroid (Hürthle cells) glands—Light and electron microscopic observations. Lab. Invest. 11: 933– 941, 1962. 23 Rutberg, U.: Ultrastructure and secretory mechanism of the parotid gland. Acta Odontol. Scand. 19 (suppl. 30): 7– 69, 1961. 24 Scott, B. L., and Pease, D. C.: Electron microscopy of the salivary and lacrimal glands of the rat. Am. J. Anat. 104: 115– 161, 1959. 25 Stewart, F. W., Foote, F. W., and Becker, W. F.: Mucoepidermoid tumors of salivary glands. Ann. Surg. 122: 820– 844, 1945. 26 Tandler, B.: Ultrastructure of the human submaxillary gland—I. Architecture and histological relationships of the secretory cells. Am. J. Anat. 111: 287– 307, 1962. 27 Tandler, B.: Ultrastructure of the human submaxillary gland—II. The base of the striated duct cells. J. Ultrastruct. Res. 9: 65– 75, 1963. 28 Thompson, A. S., and Bryant, H. C., Jr.: Histogenesis of papillary cystadenoma lymphomatosum (Warthin's tumor) of the parotid salivary gland. Am. J. Path. 26: 807– 849, 1950. 29 Watson, M. L.: Staining of tissue sections for electron microscopy with heavy metals. J. Biophys. Biochem. Cytol. 4: 475– 478. 727–730, 1958. Citing Literature Volume20, Issue41967Pages 563-571 ReferencesRelatedInformation
Referência(s)