Myocardial Depression
1984; American Medical Association; Volume: 119; Issue: 7 Linguagem: Inglês
10.1001/archsurg.1984.01390190045010
ISSN1538-3644
AutoresMarc A. Levison, Tanny Tsao, Donald D. Trunkey,
Tópico(s)Heart Rate Variability and Autonomic Control
Resumo• Previous studies from this laboratory described myocardial depression in an arterially perfused rabbit interventricular septum following perfusion with acute septic plasma. Calcium Is critical for maintenance of cardiac contractility on a beat-to-beat basis. We have investigated calcium flux in the septal tissue to determine whether altered calcium flux explains the impaired cardiac function during sepsis. Twenty-two rabbit septa were perfused with control and septic perfusate (cryoprecipitated plasma + RBCs) and calcium flux determined in seven experiments. Perfusate cations (Ca ++ , Na + , K + , and H + ) were measures, tissue function and arterial pressure were monitored. Developed tension decreased 46%, acceleration of tension change fell 42%, and arterial pressure decreased 26%, all highly significant. All septa recovered after return to control perfusate. The septic perfusate Ca ++ was significantly lower than control perfusate, while K + and H + were significantly elevated. Ion flux studies, however, could not demonstrate altered calcium flux associated with the depressed contractility. ( Arch Surg 1984;119:803-808)
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