Portal de Periódicos da CAPES

Proglumide: Selective Antagonism of Excitatory Effects of Cholecystokinin in Central Nervous System

1983; American Association for the Advancement of Science; Volume: 219; Issue: 4591 Linguagem: Inglês

10.1126/science.6828873

1095-9203

Louis A. Chiodo, Benjamin S. Bunney,

Pharmacological Receptor Mechanisms and Effects

Extracellular single-unit recording techniques were used to test the ability of proglumide to block cholecystokinin-induced excitation of rat midbrain dopaminergic neurons and dopamine-sensitive prefrontal cortex cells. Intravenous and iontophoretic proglumide administration consistently blocked cholecystokinin-induced excitations while having no effect on glutamic acid-induced increases in activity. This selective blockade of central cholecystokinin effects by proglumide suggests that this drug may be valuable for studying the possible role of cholecystokinin as a neurotransmitter or neuromodulator in the central nervous system.