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Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents

2008; Elsevier BV; Volume: 18; Issue: 4 Linguagem: Inglês

10.1016/j.bmcl.2008.01.031

1464-3405

Chunhui Zhou, Jaeki Min, Zhigang Liu, Anne W. Young, Heather Deshazer, Tian Gao, Young‐Tae Chang, Neville R. Kallenbach,

Antimicrobial Peptides and Activities

Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.