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Biocatalytic approach to enantiomerically pure β-amino acids

1995; Elsevier BV; Volume: 6; Issue: 7 Linguagem: Inglês

10.1016/0957-4166(95)00204-3

1362-511X

Vadim A. Soloshonok, Nataly A. Fokina, A. V. RYBAKOVA, Irine P. Shishkina, Sergey V. Galushko, Alexander E. Sorochinsky, Valery P. Kukhar, M. V. SAVCHENKO, Vytas K. Švedas,

Carbohydrate Chemistry and Synthesis

β-Aryl-β-amino acids were prepared in good chemical yield and high enantiomeric purity (>95% ee) via penicillin acylase-catalyzed hydrolysis of the corresponding N-phenylacetyl derivatives. The (R)-enantiomers were the fast-reacting isomers in all cases studied. The biocatalytic procedure described employs very simple set of reactions using inexpensive commercially available chemicals and enzyme, and could be easily scaled up.