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The healing of hamster skin ulcers treated with n ‐butyl‐2‐cyanoacrylate (Histoacryl blue)

1984; Wiley; Volume: 18; Issue: 6 Linguagem: Inglês

10.1002/jbm.820180602

1097-4636

Khadry Galil, G.Z. Wright, I D Schofield,

Nail Diseases and Treatments

Abstract This study was undertaken to examine the effectiveness of a commercially available n ‐butyl‐2‐cyanoacrylate (Histoacryl blue Tri‐Hawk International, 1570 Barré, Montréal, H4L 4M6 Quebec. ) as a local treatment for cutaneous ulcers. Two ulcers, approximately 0.5 cm 2 each, were made on the backs of 30 hamsters. The right side was covered with a thin film of tissue adhesive, while the left side was left untreated as a control. Animals were sacrificed at various times post‐operatively, the tissue excised, processed, and examined with the light microscope. Results showed that cyanoacrylate decreased the inflammatory exudate early in the experiment, and epithelial migration occurred slightly earlier in experimental tissue. Scab formation was absent in experimental sites until the layer of adhesive was lost. After 2 days, healing was comparable in both experimental and control, and the sites were indistinguishable histologically at day 5.