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Unit-Dose Assay of Tropine Alkaloids and Their Synthetic Analogs

1975; Elsevier BV; Volume: 64; Issue: 8 Linguagem: Inglês

10.1002/jps.2600640832

1520-6017

C. Gomaa, Aly M. Taha,

Neuroscience and Neuropharmacology Research

A charge-transfer spectrophotometric method was developed for unit-dose assay of the tropine alkaloids and some of their synthetic analogs. The high molar absorptivities of the charge-transfer bands of the alkaloids with iodine in ethylene dichloride resulted in improved recoveries and good precision, particularly at the low dose levels of pediatric and hypodermic tablets.