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Artigo Revisado por pares
BIBTEX RIS

Transforming growth factor-? blocks proliferation but not early mitogenic signaling events in T-lymphocytes

1989; Elsevier BV; Volume: 185; Issue: 2 Linguagem: Inglês

10.1016/0014-4827(89)90321-2

ISSN

1090-2422

Autores

D.G. Morris, Christine A. Kuepfer, L. E. ELLINGSWORTH, Yasuo Ogawa, P RABINOVITCH,

Tópico(s)

Axon Guidance and Neuronal Signaling

Resumo

Transforming growth factor-beta (TGF-beta) inhibits the proliferation of T-lymphocytes in response to activation with mitogenic lectin. The influence of TGF-beta on elevation of cytosolic Ca2+, induction of proliferation-associated mRNA species, and total cellular RNA content has been studied. The cells seem to exit G0 when activated in the presence of TGF-beta, but they arrest in mid-G1 phase.

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