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Immunosuppression, Hepatitis C Infection, and Acute Renal Failure in HIV-Infected Patients

2006; Lippincott Williams & Wilkins; Volume: 42; Issue: 3 Linguagem: Inglês

10.1097/01.qai.0000220165.79736.d3

1944-7884

Nora Franceschini, Sonia Napravnik, William F. Finn, Lynda A. Szczech, Joseph J. Eron,

Hepatitis C virus research

Low CD4 cell counts predict HIV-related morbidity and mortality and may be associated with acute renal failure (ARF).To estimate the effect of CD4 cell count on the incidence rate (IR) of ARF in ambulatory HIV-infected patients with access to highly active antiretroviral therapy.Observational clinical cohort of HIV-infected patients recruited from a university-based infectious diseases clinic, between 2000 and 2002, and followed up until December 31, 2002. Poisson log-linear regression models were used to calculate ARF IRs, IR differences, and IR ratios.The mean age of the 705 study participants was 40 years, two thirds were male, and 61% were African American. Incidence rates of ARF were higher at lower CD4 cell counts and among patients who were coinfected with hepatitis C. Patients with hepatitis C coinfection who also had low CD4 cell counts had the highest adjusted IR of ARF.Immunosuppression and hepatitis C virus coinfection are associated with increased IRs of ARF in ambulatory HIV-1-infected patients.