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BIBTEX RIS

Molecular epidemiology of rabies virus isolated from different sources during a bat-transmitted human outbreak occurring in Augusto Correa municipality, Brazilian Amazon

2007; Elsevier BV; Volume: 370; Issue: 2 Linguagem: Inglês

10.1016/j.virol.2007.10.005

1096-0341

Taciana Fernandes Souza Barbosa, Daniele Barbosa de Almeida Medeiros, Elizabeth Salbé Travassos da Rosa, Lívia Medeiros Neves Casseb, Rita Medeiros, Armando de Souza Pereira, Antônio Carlos Rosário Vallinoto, Marcelo Vallinoto, A. L Begot, Reynaldo José da Silva Lima, Pedro Fernando da Costa Vasconcelos, Márcio Roberto Teixeira Nunes,

Virology and Viral Diseases

We genetically characterize rabies virus (RABV) strains isolated from human cases, domestic and wild animals during a human outbreak of bat-transmitted rabies in Augusto Correa municipality, Pará state, Brazilian Amazon in 2005. Partial nucleotide sequences of the N gene (491 bp) were obtained for all strains, and phylogenetic analysis grouped these into two major clades (Pará and Central-Southeast) and identified them as bat-related viruses genotype I, Desmodus rotundus antigenic variant 3 (AgV3). A molecular clock was used to estimate the time of emergence for each RABV isolate. The molecular data from this study suggest the association of vampire bats with human and domestic animal cases reported in the outbreak, the circulation of at least two predominant lineages in the Pará state, and also a geographic association to lineages dispersion.