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Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer

2003; Springer Nature; Volume: 89; Issue: 6 Linguagem: Inglês

10.1038/sj.bjc.6601195

1532-1827

JR Goffin, Oddbjørn Straume, Pierre O. Chappuis, JS Brunet, L R Bégin, Nancy Hamel, Nora Wong, LA Akslen, William D. Foulkes,

Angiogenesis and VEGF in Cancer

Glomeruloid microvascular proliferation (GMP) in breast cancer independently adversely affected survival (relative risk 1.9, 95% CI: 1.2–3.0), particularly among women who received adjuvant chemotherapy (10-year survival 27 vs 69%, P=0.0003), and was significantly associated with p53 overexpression and BRCA1 germline mutations. The presence of GMP may influence treatment decisions.