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Association of estrogen-related polymorphisms with age at menarche, age at final menstrual period, and stages of the menopausal transition

2007; Lippincott Williams & Wilkins; Volume: 15; Issue: 1 Linguagem: Inglês

10.1097/gme.0b013e31804d2406

1530-0374

Ellen Sullivan Mitchell, Frederico M. Farin, Patricia L. Stapleton, Jesse Tsai, Eunice Y. Tao, Kathleen Smith-DiJulio, Nancy Fúgate Woods,

Phytoestrogen effects and research

In Brief Objective: To explore the association of estrogen-related polymorphisms with age at menarche, age at onset and duration of stages of the menopausal transition, and age at final menstrual period (FMP). Design: A total of 152 white women were genotyped for CYP17, CYP19 3-untranslated region, CYP19 TTTA7-13, HSDB1, CYP1A1, CYP1B1, and ESR1 polymorphisms. Analysis of variance was used to test a nonspecific model for differences among genotypes associated with each polymorphism. Results: Five of the 84 associations tested were significant at P < 0.05, which could be expected by chance. Women with two CYP19 7r alleles had menarche earlier (11.5 y) than those with one 7r allele (13.1 y). Women with two 11r alleles were 2 years older at onset of late stage than those with one 11r allele (50.7 y vs 48.6 y). Those with two 7r(-3) alleles were 2 years older at FMP than those without this allele (53.9 y vs 51.3 y). Women with the homozygous wild-type allele for HSDB1 (rs2830) were younger at FMP by 2 years than those with the heterozygous allele (50.8 y vs 52.9 y). Women with the heterozygous allele for CYP1B1*2 had a later age at menarche compared with women with the homozygous wild type (13 y vs 12.5 y). Conclusions: Age at onset of late stage and FMP and age at menarche are associated with specific genetic polymorphisms in the estrogen biosynthesis and metabolism genes. However, because of the number of comparisons, these associations may be false positives. These findings should be confirmed with a larger sample of white women. In this exploratory analysis, age at onset of late menopausal transition stage, age at onset of final menstrual period, and age at menarche were associated with CYP19 7r, 7r(-3), 11r, HSD2830, and CYP1B1*2, specific genetic polymorphisms in the estrogen biosynthesis and metabolism pathways.