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Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy

2013; Elsevier BV; Volume: 121; Issue: 24 Linguagem: Inglês

10.1182/blood-2012-12-475483

1528-0020

Benjamin Boyerinas, Maya Zafrir, Ali E. Yesilkanal, Trevor Price, Elizabeth Hyjek, Dorothy A. Sipkins,

Mesenchymal stem cell research

Key Points Stromal OPN anchors leukemia cells in prodormancy BM niches. Inhibiting this interaction leads dormant cells to proliferate, sensitizing them to chemotherapy.