The Need for Central and Peripheral Tolerance in the B Cell Repertoire
1990; American Association for the Advancement of Science; Volume: 248; Issue: 4961 Linguagem: Inglês
10.1126/science.2356469
ISSN1095-9203
AutoresChristopher C. Goodnow, Stephen Adelstein, Antony Basten,
Tópico(s)Immune Cell Function and Interaction
ResumoThe immune system normally avoids producing antibodies that react with autologous ("self") antigens by censoring self-reactive T and B cells. Unlike the T cell repertoire, antibody diversity is generated within the B cell repertoire in two phases; the first occurs by gene rearrangement in primary lymphoid organs, and the second phase involves antigen-driven hypermutation in peripheral lymphoid organs. The possibility that distinct cellular mechanisms may impose self tolerance at these two different phases of B cell diversification may explain recent findings in transgenic mouse models, in which self-reactive B cells appear to be silenced both by functional inactivation and by physical elimination.
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