Intramembrane structural differentiation in sendai virus maturation
1980; Elsevier BV; Volume: 106; Issue: 1 Linguagem: Inglês
10.1016/0042-6822(80)90219-6
ISSN1096-0341
Autores Tópico(s)Research on Leishmaniasis Studies
ResumoFreeze-fracture electron microscopy of plasma membranes of cells infected with Sendai virus reveals patches of virus-specific membrane particles arranged in a crystalline array. These structures are associated with the inner lipid leaflet of the host membrane and develop at a stage following the insertion of the external glycoproteins (spikes) into the cell surface. A crystalline organization of the membrane is recognized in those parts of the cell surface to which the spikes and nucleoprotein strands are recruited for the assembly of viral particles. After the process of viral budding, this type of structural modification of the host membrane persists only for a short time in the viral envelope: newly formed virions possess a crystalline arrangement of membrane particles which is not found in senescent virus particles.
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