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Influence of DTPA therapy on long-term effects of retained monomeric plutonium: comparison with polymeric plutonium.

1967; National Institutes of Health; Volume: 31; Issue: 3 Linguagem: Inglês

M.W. Rosenthal, A. Lindenbaum,

Medical Imaging and Pathology Studies

In mice given a single intravenous injection of 2.6 μCi of monomeric239 Pu (IV) per kilogram, 30% was in the bone from 6 to 90 days, and 21% at 300 days; 82% of the mice had at least one malignant bone tumor at death. In a second group receiving the calcium form of diethylenetriaminepentaacetic acid (DTPA) daily for 12 days, beginning 3 days after plutonium, the skeletal plutonium was reduced to 14% of the injected amount, and the final tumor incidence was 75%. In a third group, in which DTPA treatment was initiated 1 hour after plutonium, the skeletal burden was reduced to 7% of the injected amount, and the final tumor incidence was 60%. Only 1% of DTPA-control mice had a bone tumor. Average survival times after injection in these four groups were 361, 450, 556, and 650 days. The death rate of mice with bone tumors increased both with age and with time elapsed after plutonium; it decreased with decreasing plutonium concentration in bone after DTPA. DTPA removed approximately equal fractions of plutonium ...