Antidepressant drugs, convulsions and epilepsy.
1983; Wiley; Volume: 15; Issue: S2 Linguagem: Inglês
10.1111/j.1365-2125.1983.tb05878.x
ISSN1365-2125
AutoresA. Richens, S. Nawishy, M. Trimble,
Tópico(s)Metabolism and Genetic Disorders
Resumo1 Evidence concerning the convulsant effects of non-monoamine oxidase inhibitor antidepressant drugs has been reviewed. 2 Mianserin is convulsant in therapeutic doses but seizures have not been reported following overdose. 3 The convulsant effects of mianserin are probably no greater than for other non-monoamine oxidase inhibitor antidepressant drugs. 4 Enzyme-inducing anti-epileptic drugs can reduce the peak plasma concentration of mianserin and shorten its elimination half-life, probably by inducing its metabolism.
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