A highly stereocontrolled asymmetric synthesis of the Taxol C-13 side chain; (4S, 5R)-2,4-diphenyloxazoline-5-carboxylic acid
1998; Elsevier BV; Volume: 39; Issue: 44 Linguagem: Inglês
10.1016/s0040-4039(98)01804-8
ISSN1873-3581
AutoresKee‐Young Lee, Yong‐Hyun Kim, Min-Sung Park, Won‐Hun Ham,
Tópico(s)Advanced Synthetic Organic Chemistry
ResumoA stereoselective synthesis of (4S, 5R)-2,4-diphenyloxazoline-5-carboxylic acid, a precursor of the Taxol C-13 side chain was achieved using palladium-catalyzed oxazoline formation reaction from commercially available amino acid.
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