Endothelial cell conditioned media mediated regulation of glutamine synthetase activity in glial cells
1997; Elsevier BV; Volume: 104; Issue: 1-2 Linguagem: Inglês
10.1016/s0165-3806(97)00173-9
ISSN1872-6755
AutoresPolyxenie E. Spoerri, Maria B. Grant, Julissa Gomez, Antonia Vernadakis,
Tópico(s)Glioma Diagnosis and Treatment
ResumoThe responsiveness of late passage C-6 glial cells to human retinal endothelial cell-conditioned medium (HREC-CM) was examined using glutamine synthetase (GS) activity as test parameter. Treatment with 50% or 100% HREC-CM for 4-5 days slightly affected the morphology but significantly increased GS activity. Increased glial GS activity induced by vascular endothelial cells is of relevance in preventing extracellular glutamate toxicity and regulating the brain/retinal blood barrier.
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