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Quantitation of the Amount and Uniformity of Aqueous Film Coating Applied to Tablets in a 24″ Accela-Cota

1988; Taylor & Francis; Volume: 14; Issue: 5 Linguagem: Inglês

10.3109/03639048809151889

1520-5762

Paul F. Skultety, Daisy Rivera, J. K. DUNLEAVY, C. T. Lin,

Surfactants and Colloidal Systems

A simple technique was developed to quantify the amount of film coating applied to individual tablets. A Plackett-Burman experimental design was used to determine the processing parameters in a 24″ Accela-Cota which can influence the homogeniety of film coating applied to the tablets. Tablets from various locations within the coating drum were analyzed for the amount of film coating material. The processing parameters that were found to affect the film coating were: coating drum speed; amount of aqueous film coating liquid applied; and the spray pattern. The starting location of the tablets in the tablet bed did not affect the amount of coating applied or the variability of the coating. Different size and shape tablets were found to behave similarly as to what processing parameters were significant in the amount of coating applied and the variability between tablets. For individual tablets, the surface coverage was found to be very uniform.