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Glycemic response to 24 hour fast in normal children and children with ketotic hypoglycemia

1973; Elsevier BV; Volume: 82; Issue: 3 Linguagem: Inglês

10.1016/s0022-3476(73)80117-9

1097-6833

Jean‐Louis Chaussain,

Diabetes and associated disorders

A 24 hour fasting test was performed in a control group of 56 children, ages 1 to 9 years, and in a group of 10 children with a recently documental history of ketotic hypoglycemia. In the control group, the major finding was the inability of most children to sustain normal blood sugar levels during fasting. The mean blood sugar value at the end of the test was 52±14 mg. per cent, and the extent and degree of ketonuria correlated with the level of blood glucose. At the end of 24 hours of fasting, the glycemic response to glucagon was suppressed in three children. Plasma growth hormone and cortisol values at this time were slightly elevated but had no correlation with the concentration of blood sugar. Children with a history of ketotic hypoglycemiaexhibited a marked sensitivity to the fast. Their glycemia at the end of the test corresponded to the lowest values of the normal range. There were no diflerences between the groups in the intensity of the ketosis and in plasma cortisol and growth hormone levels. However, the glycemic response to glucagon after starvation was absent in 50 per cent of the children who had had ketotic hypoglycemia. Clinical tolerance to the test was excellent in both groups.